I confess that I didn’t have a lot of enthusiasm going into Prometheus (which explains why I hadn’t seen it until this). The first two-thirds worked well enough for me, but the final act really spiraled into story cliches.
Also, there isn’t sufficient character development to invest viewers in anyone deeply enough to generate an emotional response.
If you like science fiction, my favorite film in that genre in recent years is Moon. Check it out. Compelling story and a character you will care about!